Ac1.1b [Del1] (P04393) Protein Card

General Information

Name	Ac1.1b [Del1]
Organism	synthetic construct
Protein Type	Synthetic
Parent	Ac1.1b

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

GRCCHPACGKHFSC(nh2)
Modified residues	position symbol name 15 nh2 C-term amidation
Average Mass	1500.75
Monoisotopic Mass	1499.58
Isoelectric Point	11.81
Extinction Coefficient [280nm]	NA

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α1β1γδ	M. musculus	27.0nM	+/-7.1	10uM Ach	Liu,L. et al. (2007)
α2β2	R. norvegicus	>3uM		100uM Ach	Liu,L. et al. (2007)
α3β4	R. norvegicus	>5uM		100uM Ach	Liu,L. et al. (2007)

References

Liu,L., Chew,G., Hawrot,E., Chi,C. and Wang,C. (2007) Two potent alpha3/5 conotoxins from piscivorous Conus achatinus. Acta Biochim. Biophys. Sin. (Shanghai) 39:438-444

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 28 March 2023