Ac-ImI (P04404) Protein Card

General Information

Name	Ac-ImI
Organism	synthetic construct
Protein Type	Synthetic
Parent	ImI

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

(Ac)GCCSDPRCAWRC(nh2)
Modified residues	position symbol name 1 Ac N-Acetate (on N-terminus) 14 nh2 C-term amidation
Average Mass	1393.59
Monoisotopic Mass	1392.49
Isoelectric Point	NA
Extinction Coefficient [280nm]	NA

Activity

Ki: Nicotinic acetylcholine receptors

Target	Organism	Ki		Competitor	Agonist	Ref
α7-5HT3 chimaera	H. sapiens	4.2uM	+/-0.2	3.75 nM 125I-Bgtx		Quiram,P.A. and Sine,S.M. (1998)

References

Quiram,P.A. and Sine,S.M. (1998) Structural elements in alpha-conotoxin ImI essential for binding to neuronal alpha7 receptors. J. Biol. Chem. 273:11007-11011

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 28 May 2023