ImI [R7K] (P04410) Protein Card

General Information
Name ImI [R7K]
Organism synthetic construct
Protein Type Synthetic
Parent ImI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPKCAWRC(nh2)
Modified residues
positionsymbolname
13nh2C-term amidation
Average Mass 1323.54
Monoisotopic Mass 1322.48
Isoelectric Point 10.45
Extinction Coefficient [280nm] 5500.00

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
α7-5HT3 chimaeraG. gallus295uM+/-435nM I-BgtxServent,D. et al. (1998)
H. sapiens290uM+/-133.75nM 125 I-BgtxQuiram,P.A. and Sine,S.M. (1998)

References
Servent,D., Lamthanh,H., Antil,S., Bertrand,D., Corringer,P.J., Changeux,J.P. and Menez,A. (1998) Functional Determinants By Which Snake And Cone Snail Toxins Block The Alpha 7 Neuronal Nicotinic Acetylcholine Receptors J.Physiol. Paris 92:107-111
Quiram,P.A. and Sine,S.M. (1998) Structural elements in alpha-conotoxin ImI essential for binding to neuronal alpha7 receptors. J. Biol. Chem. 273:11007-11011

Internal links
Nucleic acids
Structure

External links

Tools