PnIA [L5R,A10L,sTy15Y] (P04444) Protein Card

General Information
Name PnIA [L5R,A10L,sTy15Y] (named by ConoServer)
Alternative name(s) PnIA [L5R,A10L]
Organism synthetic construct
Protein Type Synthetic
Parent PnIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSRPPCALNNPDYC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1707.92
Monoisotopic Mass 1706.64
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus4.6nM[3.7-5.8]AchDutertre,S. et al. (2007)
α7R. norvegicus10nM[8.3-13]nicotineDutertre,S. et al. (2007)

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
AChBPL. stagnalis6.2 nM+/-2.5I-Bgt(10 uM)Dutertre,S. et al. (2007)

References
Dutertre,S., Ulens,C., Büttner,R., Fish,A., van Elk,R., Kendel,Y., Hopping,G., Alewood,P.F., Schroeder,C., Nicke,A., Smit,A.B., Sixma,T.K. and Lewis,R.J. (2007) AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J. 26:3858-3867

Internal links
Nucleic acids
Structure

External links

Tools