SrIB [Gla15E] (P04445) Protein Card

General Information

Name	SrIB [Gla15E]
Organism	synthetic construct
Protein Type	Synthetic
Parent	SrIB

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

RTCCSROTCRMEYPELCG(nh2)
Modified residues	position symbol name 7 O 4-Hydroxyproline 19 nh2 C-term amidation
Average Mass	2116.44
Monoisotopic Mass	2114.86
Isoelectric Point	9.41
Extinction Coefficient [280nm]	1490.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α1β1γδ	Unknown	1.8nM	+/-1.9	50uM nicotine	López-Vera,E. et al. (2007)

Percentage inhibition: Nicotinic acetylcholine receptors

Target	Organism	% inhibition		Concentration	Agonist	Ref
α1β1γδ	Unknown	95		10uM	50uM nicotine	López-Vera,E. et al. (2007)
α3β4	Unknown	90		10uM	50uM nicotine	López-Vera,E. et al. (2007)
α4β2	Unknown	60		10uM	50uM nicotine	López-Vera,E. et al. (2007)

References

López-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano Cassulini,R., Batista,C.V., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B. and Wanke,E. (2007) Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 274:3972-3985

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023