MI [Y12M] (P04460) Protein Card

General Information
Name MI [Y12M]
Organism synthetic construct
Protein Type Synthetic
Parent MI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GRCCHPACGKNMSC(nh2)
Modified residues
positionsymbolname
15nh2C-term amidation
Average Mass 1461.72
Monoisotopic Mass 1460.53
Isoelectric Point 11.81
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δM. musculus46nM+/-71-10uM AchJacobsen,R.B. et al. (1999)
α1β1γδM. musculus19nM+/-31-10uM AchJacobsen,R.B. et al. (1999)
α1β1;γM. musculus10uM+/-21-10uM AchJacobsen,R.B. et al. (1999)

Kd: Nicotinic acetylcholine receptors

TargetOrganismKdRef
α1β1γδM. musculus32nM+/-12Jacobsen,R.B. et al. (1999)

References
Jacobsen,R.B., DelaCruz,R.G., Grose,J.H., McIntosh,J.M., Yoshikami,D. and Olivera,B.M. (1999) Critical residues influence the affinity and selectivity of alpha-conotoxin MI for nicotinic acetylcholine receptors Biochemistry 38:13310-13315

Internal links
Nucleic acids
Structure

External links

Tools