LtIA [A4S,A6P] (P04479) Protein Card

General Information
Name LtIA [A4S,A6P]
Organism synthetic construct
Protein Type Synthetic
Parent LtIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSRPACAGIHQELC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1642.90
Monoisotopic Mass 1641.66
Isoelectric Point 8.31
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus23.1nM100uM AchLuo,S. et al. (2010)

References
Luo,S., Akondi,K.B., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., Christensen,S., Dowell,C., Daly,N.L., Craik,D.J., Wang,C.I., Lewis,R.J., Alewood,P.F. and Michael McIntosh,J. (2010) Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. J. Biol. Chem. 285:12355-12366

Internal links
Nucleic acids
Structure

External links

Tools