GID [R12A] (P04481) Protein Card

General Information
Name GID [R12A]
Organism synthetic construct
Protein Type Synthetic
Parent GID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
IRD(Gla)CCSNPACAVNNOHVC
Modified residues
positionsymbolname
4GlaGamma carboxylic glutamic acid
16O4-Hydroxyproline
Average Mass 2101.28
Monoisotopic Mass 2099.79
Isoelectric Point 5.63
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus10nM1.14100uM AchNicke,A. et al. (2003)
α4β2R. norvegicus2uM0.86100uM AchNicke,A. et al. (2003)
α7R. norvegicus48nM1.26100uM AchNicke,A. et al. (2003)

References
Nicke,A., Loughnan,M.L., Millard,E.L., Alewood,P.F., Adams,D.J., Daly,N.L., Craik,D.J. and Lewis,R.J. (2003) Isolation, Structure, and Activity of GID, a Novel alpha 4/7-Conotoxin with an Extended N-terminal Sequence J. Biol. Chem. 278:3137-3144

Internal links
Nucleic acids
Structure

External links

Tools