KIIIA [K7NLeu] (P04485) Protein Card

General Information

Name	KIIIA [K7NLeu]
Organism	synthetic construct
Protein Type	Synthetic
Parent	KIIIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	III
Pharmacological family	mu conotoxin

Sequence

CCNCSS(Nle)WCRDHSRCC(nh2)
Modified residues	position symbol name 7 Nle Norleucine 17 nh2 C-term amidation
Average Mass	1869.12
Monoisotopic Mass	1867.62
Isoelectric Point	11.48
Extinction Coefficient [280nm]	5500.00

Activity

Percentage inhibition: Voltage-Gated Sodium Channels

Target	Organism	% inhibition		Concentration	Ref
Nav1.2	R. norvegicus	83	+/-2	1uM	Zhang,M.M. et al. (2007)
Nav1.4	R. norvegicus	33	+/-5	1uM	Zhang,M.M. et al. (2007)

References

Zhang,M.M., Green,B.R., Catlin,P., Fiedler,B., Azam,L., Chadwick,A., Terlau,H., McArthur,J.R., French,R.J., Gulyas,J., Rivier,J.E., Smith,B.J., Norton,R.S., Olivera,B.M., Yoshikami,D. and Bulaj,G. (2007) Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J. Biol. Chem. 282:30699-30706

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Saturday 25 March 2023