Lt28.1 precursor (P04540) Protein Card

General Information

Name	Lt28.1 precursor
Alternative name(s)	Lt15.2 precursor
Organism	Conus litteratus
Organism region	Indo-Pacific
Organism diet	vermivorous
Protein Type	Precursor

Classification

Conopeptide class	conotoxin
Gene superfamily	D superfamily
Cysteine framework	XXVIII
Pharmacological family

Sequence

MPKLEMMLLVLLILPLCYIDA VGPPPPWNMEDEIIEHWQK L HCHEISDLTPWILCSPEPLCGGKGCCAQEVCDCSGPACTCP PCL
Sequence region	[1-21] signal sequence [22-40] pro region [41-85] mature peptide Lt28.1

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Ref
α9α10	R. norvegicus	3092 nM	[1620-5901]	Lu et al. (2017)

References

Lu, J., Zhang, K., Wang, S., Sun, T., Yu, S., Dai, Q. and Liu, Z. (2017) Cloning, expression and functional characterization of a D-superfamily conotoxin Lt28. 1 with previously undescribed cysteine pattern Peptides, 94, pp.64-70 94:64-70

Internal links

Nucleic acids	Lt28.1 precursor
Structure

External links

Ncbi	ADZ76484, HM003926

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 26 September 2023