Mr1.8 precursor (P04571) Protein Card

General Information
Name Mr1.8 precursor
Alternative name(s) Mr002
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Precursor
Notes Jin et al. 2014 called this precursor with the name Mr1.7 but it was published with the name Mr1.8 by Liu et al 2012. Liu et al 2012 also published a peptide Mr1.7 which is related but not identical to to Mr1.8.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Pharmacological family

Sequence
MGMRMMFTVFLLVVLATTVV
SFTSNRVLDPAFRRRNAAAKA
SDLIALNAR
R
P
ECCTHPACHVSNPELC
S
Sequence region
[1-20]signal sequence
[51-69]mature peptideMr1.8
[52-68]mature peptideMrIC
[53-68]mature peptideMr1.8a

References
Liu,Z., Li,H., Liu,N., Wu,C., Jiang,J., Yue,J. and Dai,Q. (2012) Diversity and evolution of conotoxins in Conus virgo, Conus eburneus, Conus imperialis and Conus marmoreus from the South China Sea. Toxicon 60:982-989
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics 12:312-329
Jin,A.H., Vetter,I., Dutertre,S., Abraham,N., Emidio,N.B., Inserra,M., Murali,S.S., Christie,M.J., Alewood,P.F. and Lewis,R.J. (2014) MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors. Biochemistry 53:1-3

Internal links
Nucleic acids Conus marmoreus conotoxin Mr1.8 mRNA, complete cds.
Structure

External links
Ncbi ADZ99331

Tools