Bu8 (P04622) Protein Card

General Information
Name Bu8
Organism Conus bullatus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Bu8 precursor (4621)

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family

Sequence
CKRKGSSCRRTSYDCCTGSCRNGKC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2753.13
Monoisotopic Mass 2751.14
Isoelectric Point 12.55
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50Ref
Cav2.2R. norvegicus89 nM[85-93]Chen J et al. (2021)

Percentage inhibition: Voltage-Gated Calcium Channels

TargetOrganism% inhibitionConcentrationRef
Cav1.1R. norvegicus2.82+/-1.0210 μMChen J et al. (2021)
Cav2.1R. norvegicus27.36+/-4.4810 μMChen J et al. (2021)

Synthetic variants
Bu8[N22A]CKRKGSSCRRTSYDCCTGSCRAGKC(nh2)
Bu8[N22S]CKRKGSSCRRTSYDCCTGSCRSGKC(nh2)
Bu8[R3A]CKAKGSSCRRTSYDCCTGSCRNGKC(nh2)
Bu8[R3G]CKGKGSSCRRTSYDCCTGSCRNGKC(nh2)
Bu8[R9A]CKRKGSSCARTSYDCCTGSCRNGKC(nh2)
Bu8[R9S]CKRKGSSCSRTSYDCCTGSCRNGKC(nh2)
Bu8[S12A]CKRKGSSCRRTAYDCCTGSCRNGKC(nh2)
Bu8[S12M]CKRKGSSCRRTMYDCCTGSCRNGKC(nh2)
Bu8[S6A]CKRKGASCRRTSYDCCTGSCRNGKC(nh2)
Bu8[S7A]CKRKGSACRRTSYDCCTGSCRNGKC(nh2)
Bu8[T11A]CKRKGSSCRRASYDCCTGSCRNGKC(nh2)
Bu8[T11L]CKRKGSSCRRLSYDCCTGSCRNGKC(nh2)

References
Hu,H., Bandyopadhyay,P.K. and Yandell,M. (2011) Characterization of the Conus bullatus genome and its venom-duct transcriptome. BMC Genomics 12:60
Chen J, Liu X, Yu S, Liu J, Chen R, Zhang Y, Jiang L, Dai Q (2021) A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity. Acta Pharm Sin B 11:2685-2693

Internal links
Protein Precursor Bu8 precursor (4621)
Nucleic acids
Structure

External links

Tools