Eu1.6 (P04644) Protein Card

General Information
Name Eu1.6 (named by ConoServer)
Alternative name(s) Eb1.6
Organism Conus eburneus
Organism diet generalist
Protein Type Wild type
Protein precursor Eu1.6 precursor (4548)
Notes Eu1.6 exhibits potent analgesic activity in rat PNL and CCI models and inhibits HVA calcium currents in rodent DRG neurons.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family omega conotoxin

Sequence
GCCSNPACMLKNPNLC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1662.98
Monoisotopic Mass 1661.66
Isoelectric Point 10.45
Extinction Coefficient [280nm] -1.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50Ref
Cav2.2H. sapiens1.1 nMLiu,Z. et al. (2018)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α3β4R. norvegicus30+/-510 μMLiu,Z. et al. (2018)
α7R. norvegicus45+/-210 μMLiu,Z. et al. (2018)
α9α10R. norvegicus11+/-210 μMLiu,Z. et al. (2018)

References
Liu,Z., Bartels,P., Sadeghi,M., Du,T., Dai,Q., Zhu,C., Yu,S., Wang,S., Dong,M., Sun,T. and Guo,J. (2018) A novel α-conopeptide Eu1.6 inhibits N-type (Ca V 2.2) calcium channels and exhibits potent analgesic activity Scientific reports 8:1004

Internal links
Protein Precursor Eu1.6 precursor (4548)
Nucleic acids
Structure

External links

Tools