Mr1.7 (P04661) Protein Card

General Information
Name Mr1.7
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Mr1.7 precursor (4532)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
PECCTHPACHVSHPELC(nh2)
Modified residues
positionsymbolname
18nh2C-term amidation
Average Mass 1858.11
Monoisotopic Mass 1856.72
Isoelectric Point 6.51
Extinction Coefficient [280nm] -1.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50Ref
α2β2R. norvegicus>10 uMWang et al. (2015)
α2β4R. norvegicus>10 uMWang et al. (2015)
α3β2R. norvegicus53.1 nM[48-58.8]Wang et al. (2015)
α3β4R. norvegicus>10 uMWang et al. (2015)
α4β2R. norvegicus>10 uMWang et al. (2015)
α4β4R. norvegicus>10 uMWang et al. (2015)
α6/α3β2β3R. norvegicus284.2 nM[199.4-405.2]Wang et al. (2015)
α7R. norvegicus>10 uMWang et al. (2015)
α9α10R. norvegicus185.7 nM[154.1-223.7]Wang et al. (2015)

Synthetic variants
Mr1.7[E2A,S12N]PACCTHPACHVNHPELC(nh2)
Mr1.7[E2A]PACCTHPACHVSHPELC(nh2)
Mr1.7[H10A]PECCTHPACAVSHPELC(nh2)
Mr1.7[H13A]PECCTHPACHVSAPELC(nh2)
Mr1.7[H13N]PECCTHPACHVSNPELC(nh2)
Mr1.7[P1A]AECCTHPACHVSHPELC(nh2)
Mr1.7[S12N]PECCTHPACHVNHPELC(nh2)
Mr1.7[V11G,S12N]PECCTHPACHGNHPELC(nh2)
Mr1.7[V11G]PECCTHPACHGSHPELC(nh2)
Mr1.7[del1,E2G,V11G,S12N]GCCTHPACHGNHPELC(nh2)
MrICPECCTHPACHVSNPELC(nh2)

References
Wang, S., Zhao, C., Liu, Z., Wang, X., Liu, N., Du, W. and Dai, Q. (2015) Structural and functional characterization of a novel α-conotoxin Mr1. 7 from Conus marmoreus targeting neuronal nAChR α3β2, α9α10 and α6/α3β2β3 subtypes Marine drugs 13:3259-3275

Internal links
Protein Precursor Mr1.7 precursor (4532)
Nucleic acids
Structure

External links

Tools