cMII-7 (P00517) Protein Card

General Information
Name cMII-7
Organism synthetic construct
Protein Type Synthetic
Parent MII
Notes G17-G23: linker peptide for cyclyzation. Clark et al 2005 report that the sequence of the linker is GAGAAGG whereas the sequence in the corresponding in the NMR solution structure is GAGGAAG. The latter is reported in this card.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSNPVCHLEHSNLCGAGGAAG
Average Mass 2135.34
Monoisotopic Mass 2133.82
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

References
Clark,R.J., Fischer,H., Dempster,L., Daly,N.L., Rosengren,K.J., Nevin,S.T., Meunier,F.A., Adams,D.J. and Craik,D.J. (2005) Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII Proc. Natl. Acad. Sci. U.S.A. 102:13767-13772

Internal links
Nucleic acids
Structure STRUCTURE OF CYCLIC CONOTOXIN MII-7

External links
Ncbi 2AK0_A

Tools