RsXXVIA (P05355) Protein Card

General Information
Name RsXXVIA
Alternative name(s) RsXXIVA
Organism Conus regularis
Organism region Eastern Pacific
Organism diet vermivorous
Protein Type Wild type
Notes The framework of this peptide was described as framework XXIV (Bernáldez 2013) but this framework name was already published shortly before to another cysteine pattern (Luo 2013). The framework was therefore renamed in ConoServer to the lowest available number, XXVI, and the peptide was consequently renamed RsXXVIA (instead of RsXXIVA).

Analgesic effect in hot-plate assay [Bernáldez 2013].


Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework XXVI
Pharmacological family omega conotoxin

Sequence
CKGQSCSSCSTKEFCLSKGSRLMYDCCTGSCCGVKTAGVT
Sequence evidence protein level
Average Mass 4112.70
Monoisotopic Mass 4109.67
Isoelectric Point 11.20
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50nhillRef
Cav2.2R. norvegicus2.8uM0.94Bernáldez,J. et al. (2013)

References
Bernáldez,J., Román-González,S.A., Martínez,O., Jiménez,S., Vivas,O., Arenas,I., Corzo,G., Arreguín,R., García,D.E., Possani,L.D. and Licea,A. (2013) A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity. Mar Drugs 11:1188-1202

Internal links
Nucleic acids
Structure

External links

Tools