Vc1.1[N9F] (P05356) Protein Card

General Information

Name	Vc1.1[N9F]
Organism	synthetic construct
Protein Type	Synthetic
Parent	Vc1.1

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

GCCSDPRCFYDHPEIC(nh2)
Modified residues	position symbol name 17 nh2 C-term amidation
Average Mass	1840.04
Monoisotopic Mass	1838.66
Isoelectric Point	5.63
Extinction Coefficient [280nm]	1490.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism		IC50		Agonist	Ref
α9α10	H. sapiens	(a9 human a10 rat)	763.3nM	+/-164	50uM Ach	Yu,R. et al. (2013)
	R. norvegicus		500.0nM	+/-163	50uM Ach	Yu,R. et al. (2013)

References

Yu,R., Kompella,S.N., Adams,D.J., Craik,D.J. and Kaas,Q. (2013) Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor. J. Med. Chem.

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 5 June 2023