BuIIIB[G2a] (P05359) Protein Card

General Information

Name	BuIIIB[G2a]
Organism	synthetic construct
Protein Type	Synthetic
Parent	BuIIIB

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	III
Pharmacological family	mu conotoxin

Sequence

VaERCCKNGKRGCGRWCRDHSRCC(nh2)
Modified residues	position symbol name 2 a D-alanine 25 nh2 C-term amidation
Average Mass	2777.20
Monoisotopic Mass	2775.18
Isoelectric Point	12.36
Extinction Coefficient [280nm]	5500.00

Activity

Kd: Voltage-Gated Sodium Channels

Target	Organism	Kd		Ref
Nav1.3	R. norvegicus	4.8nM	+/-2	Kuang,Z. et al. (2013)

References

Kuang,Z., Zhang,M.M., Gupta,K., Gajewiak,J., Gulyas,J., Balaram,P., Rivier,J.E., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S. (2013) Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency. ACS Chem. Biol. 8:1344-1351

Internal links

Nucleic acids
Structure	Conotoxin analogue [D-Ala2]BuIIIB

External links

Ncbi

2LOC_A

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 27 March 2023