RegIIA precursor (P05529) Protein Card

General Information
Name RegIIA precursor
Organism Conus regius
Organism region Eastern Pacific
Organism diet vermivorous
Protein Type Precursor
Notes The publication from Franco 2012 provides the signal peptide+prepro region separated from the mature peptide region. It was here assumed that they should be connected and that there is a glycine following the mature peptide region as RegIIA has been shown to be amidated at its C-terminus. This sequence is therefore uncertain from the reference.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Pharmacological family

Sequence
MGMRMMFTVFLLVVLTTTVVSS
TSVRASDGRNAAADNRASD
LIAQIVRR
GCCSHPACNVNNPHIC
G
Sequence region
[1-22]signal sequence
[50-65]mature peptideRegIIA

References
Franco,A., Kompella,S.N., Akondi,K.B., Melaun,C., Daly,N.L., Luetje,C.W., Alewood,P.F., Craik,D.J., Adams,D.J. and Marí,F. (2012) RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochem. Pharmacol. 83:419-426

Internal links
Nucleic acids Conus regius regIIA gene for alpha-conotoxin precursor RegIIA.
Structure

External links
Ncbi CCB84446

Tools