Conantokin-G[Gla7Buc,Gla14Buc] (P05700) Protein Card

General Information

Name	Conantokin-G[Gla7Buc,Gla14Buc]
Organism	synthetic construct
Protein Type	Synthetic
Parent	Conantokin-G

Classification

Conopeptide class	conantokin
Gene superfamily
Pharmacological family

Sequence

GE(Gla)(Gla)LQ(Huc)NQ(Gla)LIR(Buc)KSN(nh2)
Modified residues	position symbol name 3 Gla Gamma carboxylic glutamic acid 4 Gla Gamma carboxylic glutamic acid 7 Huc Carbabridge [C7 alkene] (half) 10 Gla Gamma carboxylic glutamic acid 14 Buc Carbabridge [C4 alkene] (half) 18 nh2 C-term amidation
Average Mass	2169.31
Monoisotopic Mass	2168.05
Isoelectric Point	2.50
Extinction Coefficient [280nm]	NA

Activity

IC50: Ionotropic glutamate receptors

Target	Organism	IC50		Agonist	Ref
GluN2A	R. norvegicus	>10uM		200uM glutamate	Platt,R.J. et al. (2012)
GluN2B	R. norvegicus	2.04uM		200uM glutamate	Platt,R.J. et al. (2012)
GluN2C	R. norvegicus	>10uM		200uM glutamate	Platt,R.J. et al. (2012)
GluN2D	R. norvegicus	>10uM		200uM glutamate	Platt,R.J. et al. (2012)

References

Platt,R.J., Han,T.S., Green,B.R., Smith,M.D., Skalicky,J., Gruszczynski,P., White,H.S., Olivera,B., Bulaj,G. and Gajewiak,J. (2012) Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. J. Biol. Chem. 287:20727-20736

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 5 June 2023