conantokin-Rl1 (P05842) Protein Card

General Information
Name conantokin-Rl1 (named by ConoServer)
Alternative name(s) conRl-A, conantokin-Rl-A
Organism Conus rolani
Protein Type Wild type
Protein precursor conantokin-Rl1 precursor (5843)

Classification
Conopeptide class conantokin
Gene superfamily B1 superfamily
Pharmacological family

Sequence
AD(Gla)(Gla)YLKFI(Gla)EQRKQGKLDPTKFP
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
10GlaGamma carboxylic glutamic acid
Sequence evidence nucleic acid level
Average Mass 3042.31
Monoisotopic Mass 3040.47
Isoelectric Point 5.71
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2AR. norvegicus2.1uM200uM glutamateGowd,K.H. et al. (2010)
GluN2BR. norvegicus110nM200uM glutamateGowd,K.H. et al. (2010)
GluN2CR. norvegicus6.1uM200uM glutamateGowd,K.H. et al. (2010)
GluN2DR. norvegicus480nM200uM glutamateGowd,K.H. et al. (2010)

References
Gowd,K.H., Watkins,M., Twede,V.D., Bulaj,G.W. and Olivera,B.M. (2010) Characterization of conantokin Rl-A: molecular phylogeny as structure/function study. J. Pept. Sci. 16:375-382

Internal links
Protein Precursor conantokin-Rl1 precursor (5843)
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0DKY9

Tools