Conantokin-Rl2[K8N,A9Q,del10O] (P05848) Protein Card

General Information
Name Conantokin-Rl2[K8N,A9Q,del10O]
Alternative name(s) conRl-B[desKAO;N8Q9]
Organism synthetic construct
Protein Type Synthetic
Parent Conantokin-Rl2

Conopeptide class conantokin
Gene superfamily
Pharmacological family

Modified residues
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
10GlaGamma carboxylic glutamic acid
14GlaGamma carboxylic glutamic acid
18nh2C-term amidation
Average Mass 2168.08
Monoisotopic Mass 2166.84
Isoelectric Point 1.61
Extinction Coefficient [280nm] NA


IC50: Ionotropic glutamate receptors

GluN2AR. norvegicus>10uM200uM glutamateGowd,K.H. et al. (2012)
GluN2BR. norvegicus>10uM200uM glutamateGowd,K.H. et al. (2012)
GluN2CR. norvegicus>10uM200uM glutamateGowd,K.H. et al. (2012)
GluN2DR. norvegicus >10uM200uM glutamateGowd,K.H. et al. (2012)

Gowd,K.H., Han,T.S., Twede,V., Gajewiak,J., Smith,M.D., Watkins,M., Platt,R.J., Toledo,G., White,H.S., Olivera,B.M. and Bulaj,G. (2012) Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry 51:4685-4692
Kunda,S., Yuan,Y., Balsara,R.D., Zajicek,J. and Castellino,F.J. (2015) Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors. J. Biol. Chem. 290:18156-18172

Internal links
Nucleic acids
Structure The Solution Structure of the Magnesium-bound Conantokin-R1B [K8N,A9Q,del10O]

External links