Conantokin-Rl3 (P05851) Protein Card

General Information

Name	Conantokin-Rl3 (named by ConoServer)
Alternative name(s)	ConRl-C,Conantokin-RlC
Organism	Conus rolani
Protein Type	Wild type
Protein precursor	Conantokin-Rl3 precursor (5850)

Classification

Conopeptide class	conantokin
Gene superfamily	B1 superfamily
Pharmacological family

Sequence

GE(Gla)(Gla)LS(Gla)NAV(Gla)FAR(Gla)LAN(nh2)
Modified residues	position symbol name 3 Gla Gamma carboxylic glutamic acid 4 Gla Gamma carboxylic glutamic acid 7 Gla Gamma carboxylic glutamic acid 11 Gla Gamma carboxylic glutamic acid 15 Gla Gamma carboxylic glutamic acid 19 nh2 C-term amidation
Average Mass	2226.16
Monoisotopic Mass	2224.89
Isoelectric Point	1.61
Extinction Coefficient [280nm]	NA

References

Gowd,K.H., Han,T.S., Twede,V., Gajewiak,J., Smith,M.D., Watkins,M., Platt,R.J., Toledo,G., White,H.S., Olivera,B.M. and Bulaj,G. (2012) Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry 51:4685-4692

Internal links

Protein Precursor	Conantokin-Rl3 precursor (5850)
Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 26 September 2023