PeIA[E14N] (P05854) Protein Card

General Information
Name PeIA[E14N]
Alternative name(s) [Asn14]PeIA
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACSVNHPNLC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1636.85
Monoisotopic Mass 1635.62
Isoelectric Point 8.42
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus149nM+/-33100uM AchHone,A.J. et al. (2012)
α3β4R. norvegicus1.9uM+/-0.5100uM AchHone,A.J. et al. (2012)
α6/α3β2β3R. norvegicus22.0nM+/-2.6100uM AchHone,A.J. et al. (2012)
α6/α3β4H. sapiens16.2 nM[13.6-19.2]300 uM AChHone,A.J. et al. (2021)
R. norvegicus191 nM[174-209]300 uM AChHone,A.J. et al. (2021)
406nM+/-21100uM AchHone,A.J. et al. (2012)

References
Hone,A.J., Scadden,M., Gajewiak,J., Christensen,S., Lindstrom,J. and McIntosh,J.M. (2012) α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors. Mol. Pharmacol. 82:972-982
Hone,A.J., Kaas,Q., Kearns,I., Hararah,F., Gajewiak,J., Christensen,S., Craik,D.J. and McIntosh,J.M. (2021) Computational and Functional Mapping of Human and Rat α6β4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs. J Med Chem 64:1685-1700

Internal links
Nucleic acids
Structure

External links

Tools