Vc1.1 [C2(Agl),C8(Agl)] (P06292) Protein Card

General Information
Name Vc1.1 [C2(Agl),C8(Agl)] (named by ConoServer)
Alternative name(s) [2,8]-alkene dicarba Vc1.1,[2,8]-cis dicarba Vc1.1
Organism synthetic construct
Protein Type Synthetic
Parent Vc1.1

Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Modified residues
2AglCarbabridge [C2 alkene] (half)
8AglCarbabridge [C2 alkene] (half)
17nh2C-term amidation
Average Mass 1772.92
Monoisotopic Mass 1771.74
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

van Lierop,B.J., Robinson,S.D., Kompella,S.N., Belgi,A., McArthur,J.R., Hung,A., MacRaild,C.A., Adams,D.J. and Robinson,A.J. (2013) Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. ACS Chem. Biol. 8:1815-1821
Belgi,A., Burnley,J.V., MacRaild,C.A., Chhabra,S., Elnahriry,K.A., Robinson,S.D., Gooding,S.G., Tae,H.S., Bartels,P., Sadeghi,M., Zhao,F.Y., Wei,H., Spanswick,D., Adams,D.J., Norton,R.S. and Robinson,A.J. (2021) Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models. J Med Chem 64:3222-3233

Internal links
Nucleic acids
Structure Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-cis dicarba Vc1.1
Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-trans dicarba Vc1.1

External links
Ncbi 2MFX_A, 2MFY_A