Contryphan-Vc2 (P06614) Protein Card

General Information
Name Contryphan-Vc2
Organism Conus victoriae
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor contryphan-Vc2 precursor (6334)
Notes The D-Trp PTM was assumed by similarity. The L-Trp variant had similar activity by injection in mice (Drane 2017).

Drane et al., 2017 reported that the D-Trp3 of Contryphan-Vc2 was protective against enzymatic degradation.

Conopeptide class contryphan
Gene superfamily O2 superfamily
Pharmacological family

Modified residues
Sequence evidence nucleic acid level
Average Mass 862.03
Monoisotopic Mass 861.36
Isoelectric Point 11.65
Extinction Coefficient [280nm] 5500.00

Synthetic variants
Contryphan-Vc2 [w3W]CRWTPVC

Robinson,S.D., Safavi-Hemami,H., McIntosh,L.D., Purcell,A.W., Norton,R.S. and Papenfuss,A.T. (2014) Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae. PLoS ONE 9
Drane,S.B., Robinson,S.D., MacRaild,C.A., Chhabra,S., Chittoor,B., Morales,R.A., Leung,E.W., Belgi,A., Espino,S.S., Olivera,B.M., Robinson,A.J., Chalmers,D.K. and Norton,R.S. (2017) Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue. Toxicon 129:113-122

Internal links
Protein Precursor contryphan-Vc2 precursor (6334)
Nucleic acids
Structure Calculated solution structure of [D-Trp3]-Contryphan-Vc2

External links