Imi1 (P06677) Protein Card

General Information
Name Imi1
Organism synthetic construct
Protein Type Synthetic
Parent ImI

Conopeptide class conotoxin
Gene superfamily
Pharmacological family

Modified residues
Sequence evidence protein level
Average Mass 1367.59
Monoisotopic Mass 1366.51
Isoelectric Point 10.99
Extinction Coefficient [280nm] 5500.00

Maslennikov,I.V., Shenkarev,Z.O., Zhmak,M.N., Ivanov,V.T., Methfessel,C., Tsetlin,V.I. and Arseniev,A.S. (1999) NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors FEBS Lett. 444:275-280
Rogers,J.P., Luginbuhl,P., Shen,G.S., McCabe,R.T., Stevens,R.C. and Wemmer,D.E. (1999) NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors Biochemistry 38:3874-3882
Lamthanh,H., Jegou-Matheron,C., Servent,D., Menez,A. and Lancelin,J.M. (1999) Minimal conformation of the alpha-conotoxin ImI for the alpha7 neuronal nicotinic acetylcholine receptor recognition: correlated CD, NMR and binding studies FEBS Lett. 454:293-298
Gehrmann,J., Daly,N.L., Alewood,P.F. and Craik,D.J. (1999) Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance J. Med. Chem. 42:2364-2372
Ulens,C., Hogg,R.C., Celie,P.H., Bertrand,D., Tsetlin,V., Smit,A.B. and Sixma,T.K. (2006) Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP Proc. Natl. Acad. Sci. U.S.A. 103:3615-3620
Chen,S., Gopalakrishnan,R., Schaer,T., Marger,F., Hovius,R., Bertrand,D., Pojer,F. and Heinis,C. (2014) Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides Nat Chem 6:1009-1016

Internal links
Nucleic acids
Structure Solution NMR structure of peptide ImI1

External links
Ncbi 2MOA_A