AusIA (P06679) Protein Card

General Information

Name	AusIA
Organism	Conus australis
Protein Type	Wild type

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

SCCARNPACRHNHPCV
Average Mass	1764.00
Monoisotopic Mass	1762.70
Isoelectric Point	12.50
Extinction Coefficient [280nm]	-1.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism		IC50		Agonist	Ref
α7	G. gallus	(ribbon)	9.67 uM	+/-0.01	200 uM Ach	Lebbe,E.K. et al. (2014)
		(globular)	11.68 uM	+/-1.53	200 uM Ach	Lebbe,E.K. et al. (2014)

Percentage inhibition: Nicotinic acetylcholine receptors

Target	Organism		% inhibition		Concentration	Agonist	Ref
α1β1δε	R. norvegicus	(ribbon)	0			10 uM Ach	Lebbe,E.K. et al. (2014)
		(globular)	0			10 uM Ach	Lebbe,E.K. et al. (2014)
α1β1γδ	R. norvegicus	(ribbon)	0			10 uM Ach	Lebbe,E.K. et al. (2014)
		(globular)	0			10 uM Ach	Lebbe,E.K. et al. (2014)
α3β4	H. sapiens	(globular)	0			70 uM Ach	Lebbe,E.K. et al. (2014)
		(ribbon)	0			70 uM Ach	Lebbe,E.K. et al. (2014)
α4β2	H. sapiens	(ribbon)	0			50 uM Ach	Lebbe,E.K. et al. (2014)
		(globular)	0			50 uM Ach	Lebbe,E.K. et al. (2014)
α4β4	H. sapiens	(globular)	0			50 uM Ach	Lebbe,E.K. et al. (2014)
		(ribbon)	0			50 uM Ach	Lebbe,E.K. et al. (2014)
α7	G. gallus	(globular)	40			200 uM Ach	Lebbe,E.K. et al. (2014)
		(ribbon)	51			200 uM Ach	Lebbe,E.K. et al. (2014)

References

Lebbe,E.K., Peigneur,S., Maiti,M., Mille,B.G., Devi,P., Ravichandran,S., Lescrinier,E., Waelkens,E., D'Souza,L. and Tytgat,J. (2014) Discovery of a new subclass of α-conotoxins in the venom of Conus australis. Toxicon 91:145-154

Internal links

Nucleic acids
Structure

External links

Ncbi

P0DL39

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023