LsIA deamidated (P06777) Protein Card

General Information
Name LsIA deamidated (named by ConoServer)
Alternative name(s) LsIA#
Organism synthetic construct
Protein Type Synthetic
Parent LsIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
SGCCSNPACRVNNPNIC
Average Mass 1747.95
Monoisotopic Mass 1746.67
Isoelectric Point 10.94
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus3.3 nM[2.2-5.1]-150 uM AchInserra,M.C. et al. (2013)
α7H. sapiens30.7 nM[21.7-43.4]-1.5200 uM AchInserra,M.C. et al. (2013)

References
Inserra,M.C., Kompella,S.N., Vetter,I., Brust,A., Daly,N.L., Cuny,H., Craik,D.J., Alewood,P.F., Adams,D.J. and Lewis,R.J. (2013) Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochem. Pharmacol. 86:791-799

Internal links
Nucleic acids
Structure

External links

Tools