LsIA [del1] (P06778) Protein Card

General Information
Name LsIA [del1] (named by ConoServer)
Alternative name(s) [Δ1] LsIA
Organism synthetic construct
Protein Type Synthetic
Parent LsIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSNPACRVNNPNIC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1659.88
Monoisotopic Mass 1658.65
Isoelectric Point 11.16
Extinction Coefficient [280nm] 500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus56.2 nM[40.4-78.2]-150 uM AchInserra,M.C. et al. (2013)
α7H. sapiens23.0 nM[19.3-27.5]-2200 uM AchInserra,M.C. et al. (2013)

References
Inserra,M.C., Kompella,S.N., Vetter,I., Brust,A., Daly,N.L., Cuny,H., Craik,D.J., Alewood,P.F., Adams,D.J. and Lewis,R.J. (2013) Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochem. Pharmacol. 86:791-799

Internal links
Nucleic acids
Structure

External links

Tools