LsIA [del1-2] (P06779) Protein Card

General Information

Name	LsIA [del1-2] (named by ConoServer)
Organism	synthetic construct
Protein Type	Synthetic
Parent	LsIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

CCSNPACRVNNPNIC(nh2)

Modified residues

position	symbol	name
16	nh2	C-term amidation

Average Mass

1602.83

Monoisotopic Mass

1601.63

Isoelectric Point

11.65

Extinction Coefficient [280nm]

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		n_hill	Agonist	Ref
α3β2	R. norvegicus	92.4 nM	[69.3-123.3]	-0.9	50 uM Ach	Inserra,M.C. et al. (2013)
α7	H. sapiens	44.1 nM	[37.1-52.4]	-2.5	200 uM Ach	Inserra,M.C. et al. (2013)

References

Inserra,M.C., Kompella,S.N., Vetter,I., Brust,A., Daly,N.L., Cuny,H., Craik,D.J., Alewood,P.F., Adams,D.J. and Lewis,R.J. (2013) Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochem. Pharmacol. 86:791-799

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 29 November 2023