PeIA[P6O] (P06784) Protein Card

General Information

Name	PeIA[P6O]
Organism	synthetic construct
Protein Type	Synthetic
Parent	PeIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

GCCSHOACSVNHPELC(nh2)

Modified residues

position	symbol	name
6	O	4-Hydroxyproline
17	nh2	C-term amidation

Sequence evidence

Unknown

Average Mass

1667.86

Monoisotopic Mass

1666.61

Isoelectric Point

6.81

Extinction Coefficient [280nm]

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α3β2	R. norvegicus	25.1 uM	+/-12.4	100 uM Ach	Hone,A.J. et al. (2013)
α6/α3β2β3	R. norvegicus	2.2 uM	+/-2.2	100 uM Ach	Hone,A.J. et al. (2013)

References

Hone,A.J., Ruiz,M., Scadden,M., Christensen,S., Gajewiak,J., Azam,L. and McIntosh,J.M. (2013) Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. 288:25428-25439

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 28 March 2023