PeIA[P13A] (P06788) Protein Card

General Information
Name PeIA[P13A]
Alternative name(s) [Ala13]PeIA
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Modified residues
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1625.82
Monoisotopic Mass 1624.60
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA


IC50: Nicotinic acetylcholine receptors

α3β2R. norvegicus63.0 nM+/-12.5100 uM AchHone,A.J. et al. (2013)
α6/α3β2β3R. norvegicus13.3 nM+/-2.6100 uM AchHone,A.J. et al. (2013)
α6/α3β4H. sapiens73.3 nM[66.8-80.5]300 uM AChHone et al. (2018)
73.3 nM[66.8-80.5]300 uM AChHone,A.J. et al. (2021)
R. norvegicus381 nM[317-456]300 uM AChHone et al. (2018)
381 nM[317-456]300 uM AChHone,A.J. et al. (2021)

Hone,A.J., Ruiz,M., Scadden,M., Christensen,S., Gajewiak,J., Azam,L. and McIntosh,J.M. (2013) Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. 288:25428-25439
Hone, A.J., Talley, T.T., Bobango, J., Melo, C.H., Hararah, F., Gajewiak, J., Christensen, S., Harvey, P.J., Craik, D.J. and McIntosh, J.M. (2018) Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors Journal of Biological Chemistry 293:17838-17852
Hone,A.J., Kaas,Q., Kearns,I., Hararah,F., Gajewiak,J., Christensen,S., Craik,D.J. and McIntosh,J.M. (2021) Computational and Functional Mapping of Human and Rat α6β4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs. J Med Chem 64:1685-1700

Internal links
Nucleic acids

External links