PeIA[N11K] (P06799) Protein Card

General Information
Name PeIA[N11K]
Alternative name(s) [Lys11]PeIA
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACSVKHPELC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1665.93
Monoisotopic Mass 1664.67
Isoelectric Point 8.42
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus45.4 uM +/-18.3100 uM AchHone,A.J. et al. (2013)
α6/α3β2β3R. norvegicus40.8 nM+/-12.5100 uM AchHone,A.J. et al. (2013)
α6/α3β4H. sapiens1.46 nM[1.28-1.66]300 uM AChHone,A.J. et al. (2021)
R. norvegicus44.5 nM[37.8-52.3]300 uM AChHone,A.J. et al. (2021)

References
Hone,A.J., Ruiz,M., Scadden,M., Christensen,S., Gajewiak,J., Azam,L. and McIntosh,J.M. (2013) Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. 288:25428-25439
Hone,A.J., Kaas,Q., Kearns,I., Hararah,F., Gajewiak,J., Christensen,S., Craik,D.J. and McIntosh,J.M. (2021) Computational and Functional Mapping of Human and Rat α6β4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs. J Med Chem 64:1685-1700

Internal links
Nucleic acids
Structure

External links

Tools