SuVIA (P06805) Protein Card

General Information
Name SuVIA
Alternative name(s) delta-SuVIA
Organism Conus suturatus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Notes Suggested early evolution in Conidae (Jin et al. 2015). A wide occurrence of delta-conotoxin-like sequences in worm hunting species. Present in the proximal part of the venom gland indicating a defensive role.

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family delta conotoxin

Sequence
CAGIGSFCGLPGLVDCCSDRCFIVCLP
Sequence evidence protein level
Average Mass 2743.25
Monoisotopic Mass 2741.16
Isoelectric Point 4.50
Extinction Coefficient [280nm] NA

Activity

EC50: Voltage-Gated Sodium Channels

TargetOrganismEC50Ref
Nav1.3H. sapiens(veratridine)3.98 nM+/-0.97Jin,A.H. et al. (2015)
Nav1.4H. sapiens(veratridine)4.99 nM+/-0.92Jin,A.H. et al. (2015)
Nav1.6H. sapiens(veratridine)1.27 nM+/-0.56Jin,A.H. et al. (2015)
Nav1.7H. sapiens(veratridine)2.42 nM+/-0.12Jin,A.H. et al. (2015)

References
Jin,A.H., Israel,M.R., Inserra,M.C., Smith,J.J., Lewis,R.J., Alewood,P.F., Vetter,I. and Dutertre,S. (2015) δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proc. Biol. Sci. 282

Internal links
Nucleic acids
Structure

External links

Tools