GeXXA[del1-20] (P06856) Protein Card

General Information
Name GeXXA[del1-20] (named by ConoServer)
Alternative name(s) GeXXA-CTD
Organism synthetic construct
Protein Type Synthetic
Parent GeXXA
Notes Xu et al (2015) determined that GeXXA-CTD retains inhibitory activity against a9a10 nAChR subtype.

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TRLCSTMCCARADCTCVYHTWRGHGCSCVM
Sequence evidence protein level
Average Mass 3349.89
Monoisotopic Mass 3347.29
Isoelectric Point 11.18
Extinction Coefficient [280nm] 7115.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α9α10H. sapiens2.02 uM[1.82-2.25]-1.7ACh (50uM)Xu,S. et al. (2015)
R. norvegicus198 nM[164-238]-1.7ACh (50uM)Xu,S. et al. (2015)
synthetic construct(Mutant receptor with Homo Sapien a9 and Rattus a10)224 nM[194-258]-1.4ACh (50uM)Xu,S. et al. (2015)
(Mutnt (L7H))183 nM[132-255]-2.8ACh( 50uM)Xu,S. et al. (2015)

References
Xu,S., Zhang,T., Kompella,S.N., Yan,M., Lu,A., Wang,Y., Shao,X., Chi,C., Adams,D.J., Ding,J. and Wang,C. (2015) Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep 5:14261

Internal links
Nucleic acids
Structure

External links

Tools