ViIA[R1A] (P06861) Protein Card

General Information

Name	ViIA[R1A]
Organism	synthetic construct
Protein Type	Synthetic
Parent	ViIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

ADCCSNPPCAHNNPDC(nh2)
Modified residues	position symbol name 17 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1655.76
Monoisotopic Mass	1654.54
Isoelectric Point	4.50
Extinction Coefficient [280nm]	NA

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α3β2	R. norvegicus	532.4 nM	[428.5-661.5]	ACh (100 uM)	Li,L. et al. (2015)

Percentage inhibition: Nicotinic acetylcholine receptors

Target	Organism	% inhibition		Concentration	Agonist	Ref
α3β2	R. norvegicus	0		95	ACh (100 uM)	Li,L. et al. (2015)

References

Li,L., Liu,N., Ding,R., Wang,S., Liu,Z., Li,H., Zheng,X. and Dai,Q. (2015) A novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype. Acta Biochim. Biophys. Sin. (Shanghai) 47:1023-1028

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 27 September 2023