VilA[D2A] (P06862) Protein Card

General Information
Name VilA[D2A]
Organism synthetic construct
Protein Type Synthetic
Parent ViIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
RACCSNPPCAHNNPDC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1696.86
Monoisotopic Mass 1695.61
Isoelectric Point 7.88
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus854.1 nM[665.1-1113.5]ACh (100 uM)Li,L. et al. (2015)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α3β2R. norvegicus095ACh (100 uM)Li,L. et al. (2015)

References
Li,L., Liu,N., Ding,R., Wang,S., Liu,Z., Li,H., Zheng,X. and Dai,Q. (2015) A novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype. Acta Biochim. Biophys. Sin. (Shanghai) 47:1023-1028

Internal links
Nucleic acids
Structure

External links

Tools