VilA deamidated (P06864) Protein Card

General Information
Name VilA deamidated (named by ConoServer)
Alternative name(s) VilA-l
Organism synthetic construct
Protein Type Synthetic
Parent ViIA
Notes Disulfide connectivity of VilA-l is C1-C4, C2-C3 (Li et al 2015)

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
RDCCSNPPCAHNNPD(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Sequence evidence protein level
Average Mass 1638.74
Monoisotopic Mass 1637.60
Isoelectric Point 5.80
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus>10000 nMACh (100 uM)Li,L. et al. (2015)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α3β2R. norvegicus095ACh (100 uM)Li,L. et al. (2015)

References
Li,L., Liu,N., Ding,R., Wang,S., Liu,Z., Li,H., Zheng,X. and Dai,Q. (2015) A novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype. Acta Biochim. Biophys. Sin. (Shanghai) 47:1023-1028

Internal links
Nucleic acids
Structure

External links

Tools