Conorphin-1 (P06865) Protein Card

General Information

Name	Conorphin-1
Organism	synthetic construct
Protein Type	Synthetic
Notes	The study by Deuis et al (2015) suggests that targeting the K-opoid receptors in peripheral sensory nerve endings innervating the skin with conorphin-1 is not a viable analgesic approach.

Classification

Conopeptide class	conorphin
Gene superfamily
Pharmacological family

Sequence

(Bnz)PrrQ(TBG)CC
Modified residues	position symbol name 1 Bnz N-term benzoyl 3 r D-arginine 4 r D-arginine 6 TBG Tert-Butyl Glycine
Sequence evidence	protein level
Average Mass	994.17
Monoisotopic Mass	993.44
Isoelectric Point	NA
Extinction Coefficient [280nm]	NA

Activity

EC50: Opioid receptors

Target	Organism	EC50		Ref
κ	H. sapiens	2.2 M	+/-0.07	Deuis,J.R. et al. (2015)

Percentage inhibition: Opioid receptors

Target	Organism		% inhibition		Concentration	Agonist	Ref
δ	H. sapiens	(No significant effect of Conorphin-1 concentrations of up to 1uM)	0			Forksolin (50 uM)	Deuis,J.R. et al. (2015)
μ	H. sapiens	(No significant effect of Conorphin-1 concentrations of up to 1uM)	0			Forksolin (50 uM)	Deuis,J.R. et al. (2015)

Percentage inhibition: Voltage-Gated Sodium Channels

Target	Organism		% inhibition		Concentration	Agonist	Ref
Nav1.1	H. sapiens	(No inhibition using Conorphin-1 concentrations of up to 1uM)	0			Veratridine (60 uM)	Deuis,J.R. et al. (2015)
Nav1.2	H. sapiens	(No inhibition using Conorphin-1 concentrations of up to 1uM)	0			Veratridine (60 uM)	Deuis,J.R. et al. (2015)
Nav1.3	H. sapiens	(No inhibition using Conorphin-1 concentrations of up to 1uM)	0			Veratridine (60 uM)	Deuis,J.R. et al. (2015)
Nav1.4	H. sapiens	(No inhibition using Conorphin-1 concentrations of up to 1uM)	0			Veratridine (60 uM)	Deuis,J.R. et al. (2015)
Nav1.5	H. sapiens	(No inhibition using Conorphin-1 concentrations of up to 1uM)	0			Veratridine (60 uM)	Deuis,J.R. et al. (2015)
Nav1.6	H. sapiens	(No inhibition using Conorphin-1 concentrations of up to 1uM)	0			Veratridine (60 uM)	Deuis,J.R. et al. (2015)
Nav1.7	H. sapiens	(No inhibition using Conorphin-1 concentrations of up to 1uM)	0			Veratridine (60 uM)	Deuis,J.R. et al. (2015)
Nav1.8	H. sapiens	(No inhibition using Conorphin-1 concentrations of up to 1uM)	0			deltamethrin (150 uM)	Deuis,J.R. et al. (2015)

References

Deuis,J.R., Whately,E., Brust,A., Inserra,M.C., Asvadi,N.H., Lewis,R.J., Alewood,P.F., Cabot,P.J., and Vetter,I. (2015) Activation of κ opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia ACS Chemical Neuroscience 6:1751-1758

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 29 March 2023