Conorphin-T[N1U,del2,3] (P06907) Protein Card

General Information
Name Conorphin-T[N1U,del2,3] (named by ConoServer)
Alternative name(s) 11
Organism synthetic construct
Protein Type Synthetic
Parent Conorphin-T[ribbon]

Classification
Conopeptide class conorphin
Gene superfamily
Pharmacological family

Sequence
ZRRQICC(nh2)
Modified residues
positionsymbolname
1ZPyroglutamic acid
8nh2C-term amidation
Sequence evidence protein level
Average Mass 886.06
Monoisotopic Mass 885.41
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

EC50: Opioid receptors

TargetOrganismEC50Ref
κsynthetic construct(ERK 1/2 phosphorylation assay)7486 nM+/-1701Brust,A. et al. (2016)
(cAMP inhibition assay)1.9 nM+/-1.7Brust,A. et al. (2016)

Ki: Opioid receptors

TargetOrganismKiCompetitorAgonistRef
κsynthetic construct191 nM+/-35Brust,A. et al. (2016)

References
Brust,A., Croker,D.E., Colless,B., Ragnarsson,L., Andersson,A., Jain,K., Garcia-Caraballo,S., Castro,J., Brierley,S.M., Alewood,P.F., Lewis,R.J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J Med Chem

Internal links
Nucleic acids
Structure

External links

Tools