Conorphin-T[R5(Cit),ribbon] (P06918) Protein Card

General Information
Name Conorphin-T[R5(Cit),ribbon] (named by ConoServer)
Alternative name(s) 22(1-2,3-4)
Organism synthetic construct
Protein Type Wild type
Parent Conorphin-T[ribbon]

Classification
Conopeptide class conorphin
Gene superfamily
Cysteine framework V
Pharmacological family rho conotoxin

Sequence
NCCR(Cit)QICC(nh2)
Modified residues
positionsymbolname
5CitCitrulline
10nh2C-term amidation
Sequence evidence protein level
Average Mass 1094.30
Monoisotopic Mass 1093.40
Isoelectric Point 10.50
Extinction Coefficient [280nm] NA

Activity

Ki: Opioid receptors

TargetOrganismKiCompetitorAgonistRef
κsynthetic construct387 nM+/-127Brust,A. et al. (2016)

References
Brust,A., Croker,D.E., Colless,B., Ragnarsson,L., Andersson,A., Jain,K., Garcia-Caraballo,S., Castro,J., Brierley,S.M., Alewood,P.F., Lewis,R.J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J Med Chem

Internal links
Nucleic acids
Structure

External links

Tools