Conorphin-T[N1U,del2-3,I7(Cha)] (P06919) Protein Card

General Information

Name	Conorphin-T[N1U,del2-3,I7(Cha)] (named by ConoServer)
Alternative name(s)	23
Organism	synthetic construct
Protein Type	Synthetic
Parent	Conorphin-T[ribbon]

Classification

Conopeptide class	conorphin
Gene superfamily
Pharmacological family

Sequence

ZRRQ(Cha)CC(nh2)
Modified residues	position symbol name 1 Z Pyroglutamic acid 5 Cha Cyclohexylalanine 8 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	926.12
Monoisotopic Mass	925.44
Isoelectric Point	NA
Extinction Coefficient [280nm]	NA

Activity

EC50: Opioid receptors

Target	Organism		EC50		Ref
κ	synthetic construct	(ERK 1/2 phosphorylation assay)	1580 nM	+/-439	Brust,A. et al. (2016)
		(cAMP inhibition assay)	15.2 nM	+/-7.4	Brust,A. et al. (2016)

Ki: Opioid receptors

Target	Organism		Ki		Competitor	Agonist	Ref
κ	synthetic construct		6.17 nM	+/-1.1			Brust,A. et al. (2016)

References

Brust,A., Croker,D.E., Colless,B., Ragnarsson,L., Andersson,A., Jain,K., Garcia-Caraballo,S., Castro,J., Brierley,S.M., Alewood,P.F., Lewis,R.J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J Med Chem

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Thursday 1 June 2023