Con-ins T2 precursor (P06930) Protein Card

General Information

Name	Con-ins T2 precursor
Organism	Conus tulipa (tulip cone)
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Precursor
Notes	Sequence regions were predicted based on alignment with known insulins.

Classification

Conopeptide class	coninsulin
Gene superfamily	Insulin superfamily
Pharmacological family

Sequence

MTTSFYFLLMALGLLLYVCQS SFGNQHTR NSDTPKYRCGSD IPNSYMDLCFR KRNDAGKKRGQASPLWQRGGSLSMLKARAK RNEAFHLQRAHR GVVEHCCYRPCSNAEFKKFCG
Sequence evidence	nucleic acid level
Sequence region	[1-21] signal sequence [30-52] mature peptide Con-ins T2 B chain [53-94] pro region C peptide [95-115] mature peptide Con-ins T2 A chain

References

Safavi-Hemami,H., Gajewiak,J., Karanth,S., Robinson,S.D., Ueberheide,B., Douglass,A.D., Schlegel,A., Imperial,J.S., Watkins,M., Bandyopadhyay,P.K., Yandell,M., Li,Q., Purcell,A.W., Norton,R.S., Ellgaard,L. and Olivera,B.M. (2015) Specialized insulin is used for chemical warfare by fish-hunting cone snails. Proc. Natl. Acad. Sci. U.S.A. 112:1743-1748

Internal links

Nucleic acids	Con-ins T2 mRNA
Structure

External links

Ncbi

AJD85827

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 28 May 2023