GVIIJ[(Btr)2W,(Scc)24S] (P06956) Protein Card

General Information

Name	GVIIJ[(Btr)2W,(Scc)24S] (named by ConoServer)
Alternative name(s)	GVIIJ[C24S]
Organism	synthetic construct
Protein Type	Synthetic
Parent	GVIIJ
Notes	Block of rat Nav1.2 is rapidly reversible (Green et al., 2016).

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family	mu conotoxin

Sequence

GWCGDOGATCGKLRLYCCSGFCDSYTKTCKDKSSA

Modified residues

position	symbol	name
6	O	4-Hydroxyproline

Sequence evidence

protein level

Average Mass

3723.16

Monoisotopic Mass

3720.52

Isoelectric Point

10.68

Extinction Coefficient [280nm]

8480.00

Activity

IC50: Voltage-Gated Sodium Channels

Target	Organism	IC50		Ref
Na_v1.2	R. norvegicus	4.8 Î¼m	[3.7-6.2]	Green,B.R. et al. (2016)

References

Green,B.R., Gajewiak,J., Chhabra,S., Skalicky,J.J., Zhang,M.M., Rivier,J.E., Bulaj,G., Olivera,B.M., Yoshikami,D. and Norton,R.S. (2016) Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem. 291:7205-7220

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 28 March 2023