PiVIIA (P06978) Protein Card

General Information

Name	PiVIIA
Organism	Conus princeps (Prince cone)
Organism region	Eastern Pacific
Protein Type	Wild type
Notes	Perfusion with this conotoxin has no effect on sodium, potassium or ASIC currents. Calcium currents are enhanced by toxin perfusion. (Whole cell patch clamp of rat DRG neurons, Bernáldez et al. 2016).

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family	gamma conotoxin

Sequence

CDAOTHYCTNYW(Gla)CCSGYC(Gla)HSHCW
Modified residues	position symbol name 4 O 4-Hydroxyproline 13 Gla Gamma carboxylic glutamic acid 20 Gla Gamma carboxylic glutamic acid
Sequence evidence	protein level
Average Mass	3097.22
Monoisotopic Mass	3094.94
Isoelectric Point	6.60
Extinction Coefficient [280nm]	15470.00

References

Bernáldez,J., Jiménez,S., González,L.J., Ferro,J.N., Soto,E., Salceda,E., Chávez,D., Aguilar,M.B. and Licea-Navarro,A. (2016) A New Member of Gamma-Conotoxin Family Isolated from Conus princeps Displays a Novel Molecular Target. Toxins (Basel) 8:39

Internal links

Nucleic acids
Structure

External links

UniProtKB/Swiss-Prot	P0DOW6.1
Ncbi	O27A_CONPG

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Thursday 1 June 2023