BuIIIB[C5U,C6A,C17U,C23A] (P06982) Protein Card

General Information
Name BuIIIB[C5U,C6A,C17U,C23A]
Alternative name(s) ddSecBuIIIB
Organism synthetic construct
Protein Type Synthetic
Parent BuIIIB
Notes Hα chemical shift deviations from random coil suggested that the N-terminus was largely unstructured. Green,B.R., et al (2014)

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family mu conotoxin

Sequence
VGER(Sec)AKNGKRGCGRW(Sec)RDHSRAC(nh2)
Modified residues
positionsymbolname
5SecSelenocysteine
17SecSelenocysteine
25nh2C-term amidation
Average Mass 2665.67
Monoisotopic Mass 2789.15
Isoelectric Point 12.36
Extinction Coefficient [280nm] 5500.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.3R. norvegicus0.2 μM+/-0.04Green,B.R. et al. (2014)
Nav1.4R. norvegicus0.001 μMGreen,B.R. et al. (2014)

References
Green,B.R., Zhang,M.M., Chhabra,S., Robinson,S.D., Wilson,M.J., Redding,A., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S. (2014) Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. FEBS J. 281:2885-2898

Internal links
Nucleic acids
Structure

External links

Tools