BuIIIB[C5U,C6A,C17U,S21A,C23A] (P07000) Protein Card

General Information

Name	BuIIIB[C5U,C6A,C17U,S21A,C23A]
Organism	synthetic construct
Protein Type	Synthetic
Parent	BuIIIB

Classification

Conopeptide class	conotoxin
Gene superfamily
Pharmacological family	mu conotoxin

Sequence

VGER(Sec)AKNGKRGCGRW(Sec)RDHARAC(nh2)
Modified residues	position symbol name 5 Sec Selenocysteine 17 Sec Selenocysteine 25 nh2 C-term amidation
Average Mass	2649.67
Monoisotopic Mass	2773.15
Isoelectric Point	12.36
Extinction Coefficient [280nm]	5500.00

Activity

Kd: Voltage-Gated Sodium Channels

Target	Organism	Kd		Ref
Nav1.3	R. norvegicus	0.37 μM	+/-0.059	Green,B.R. et al. (2014)
Nav1.4	R. norvegicus	0.005 μM	+/-0.001	Green,B.R. et al. (2014)

References

Green,B.R., Zhang,M.M., Chhabra,S., Robinson,S.D., Wilson,M.J., Redding,A., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S. (2014) Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. FEBS J. 281:2885-2898

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 27 March 2023