Conantokin-SuB (P07401) Protein Card

General Information
Name Conantokin-SuB (named by ConoServer)
Alternative name(s) Con-BkB
Organism Conus sulcatus
Organism region Indo-Pacific
Protein Type Wild type
Protein precursor Conantokin-SuB precursor incomplete (7402)
Notes Platt et al., 2014 reported that CD measurements indicated low helicity in presence of Ca2+. Conus bocki is renamed as Conus Sulcatus

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GE(Gla)(Gla)YS(Gla)AI(nh2)
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
10nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1157.06
Monoisotopic Mass 1156.40
Isoelectric Point 1.90
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50nhillRef
GluN2AR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)3.9 uM+/-0.2-1.3Platt,R.J. et al. (2014)
GluN2BR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)5.1 uM+/-0.2-1.2Platt,R.J. et al. (2014)
GluN2CR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)3.9 uM+/-0.1-0.8Platt,R.J. et al. (2014)
GluN2DR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)1.91 uM+/-0.06-0.9Platt,R.J. et al. (2014)

Synthetic variants
Conantokin-SuB deamidatedGE(Gla)(Gla)YS(Gla)AI
Conantokin-SuB[A8F]GE(Gla)(Gla)YS(Gla)FI(nh2)
Conantokin-SuB[S6A,A8F]GE(Gla)(Gla)YA(Gla)FI

References
Platt,R.J., Curtice,K.J., Twede,V.D., Watkins,M., Gruszczyński,P., Bulaj,G., Horvath,M.P., and Olivera,B.M. (2014) From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon 81:67-79

Internal links
Protein Precursor Conantokin-SuB precursor incomplete (7402)
Nucleic acids
Structure NMDA receptor antagonist: Con-BkB NMR solution structure

External links
Ncbi 2M7R_A

Tools