Conantokin-SuC (P07403) Protein Card

General Information
Name Conantokin-SuC (named by ConoServer)
Alternative name(s) Con-BkC
Organism Conus sulcatus
Organism region Indo-Pacific
Protein Type Wild type
Protein precursor Conantokin-SuC precursor incomplete (7404)
Notes Platt et al.,2014 reported that CD measurements indicated low helicity in presence of Ca2+. Conus bocki is renamed as Conus Sulcatus

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
DD(Gla)(Gla)YA(Gla)FI(Gla)QQR(Gla)AGLV
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
10GlaGamma carboxylic glutamic acid
14GlaGamma carboxylic glutamic acid
Sequence evidence protein level
Average Mass 2361.28
Monoisotopic Mass 2359.91
Isoelectric Point 2.21
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50nhillRef
GluN2AR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)0.9 uM+/-0.1-1.4Platt,R.J. et al. (2014)
GluN2BR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)0.37 uM+/-0.07-1.6Platt,R.J. et al. (2014)
GluN2CR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)1.5 uM+/-0.07-1.2Platt,R.J. et al. (2014)
GluN2DR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)0.17 uM+/-0.02-0.93Platt,R.J. et al. (2014)

Synthetic variants
Conantokin-SuC[del10-18]DD(Gla)(Gla)YA(Gla)FI(nh2)

References
Platt,R.J., Curtice,K.J., Twede,V.D., Watkins,M., Gruszczyński,P., Bulaj,G., Horvath,M.P., and Olivera,B.M. (2014) From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon 81:67-79

Internal links
Protein Precursor Conantokin-SuC precursor incomplete (7404)
Nucleic acids
Structure

External links

Tools